Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway

作     者：Kimber, Ian Poole, Alan Basketter, David A. 

作者机构：Univ Manchester Fac Biol Med & Hlth Oxford Rd Manchester M13 9PT Lancs England European Ctr Ecotoxicol & Toxicol Chem ECETOC 2 Ave E Van Nieuwenhuyse B-1160 Brussels Belgium DABMEB Consultancy Ltd Sharnbrook MK44 1PR Beds England 

出 版 物：《TOXICOLOGY RESEARCH》 (Toxicol. Res.)

年 卷 期：2018年第7卷第4期

页      面：586-605页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

主　　题：aspect-oriented programming chemical compounds allergic asthma epidermis (animal) sensitization Respiratory Tract skin Allergens 

摘      要：Sensitisation of the respiratory tract to chemicals resulting in respiratory allergy and allergic asthma is an important occupational health problem, and presents toxicologists with no shortage of challenges. A major issue is that there are no validated or, even widely recognised, methods available for the identification and characterisation of chemical respiratory allergens, or for distinguishing respiratory allergens from contact allergens. The first objective here has been review what is known (and what is not known) of the mechanisms through which chemicals induce sensitisation of the respiratory tract, and to use this information to construct a hybrid Adverse Outcome Pathway (AOP) that combines consideration of both skin and respiratory sensitisation. The intention then has been to use the construction of this hybrid AOP to identify areas of commonality/confluence, and areas of departure/divergence, between skin sensitisation and sensitisation of the respiratory tract. The hybrid AOP not only provides a mechanistic understanding of how the processes of skin and respiratory sensitisation differ, buy also a means of identifying areas of uncertainty about chemical respiratory allergy that benefit from a further investment in research.