Immunohistochemical study of hormonal receptors and cell proliferation in normal canine mammary glands and spontaneous mammary tumours

作     者：Geraldes, M Gärtner, F Schmitt, F 

作者机构：Univ Porto Inst Mol Pathol & Immunol P-4200 Oporto Portugal 

出 版 物：《VETERINARY RECORD》 (兽医记录)

年 卷 期：2000年第146卷第14期

页      面：403-406页

核心收录：

学科分类：0906[农学-兽医学] 09[农学] 

主　　题：细胞分裂 狗疾病/病理学 乳腺 动物/病理学 乳房肿瘤 动物/病理学 受体 细胞表面/分离和提纯 动物 狗 女(雌)性 

摘      要：The expression of hormone receptors and their relationship-to cell proliferation in six samples of normal canine mammary tissue, and 11 benign and 10 malignant mammary neoplasms from female dogs were assessed by immunohistochemistry in formalin-fixed paraffin-embedded samples, by using monoclonal antibodies against progesterone and oestrogen receptors, and nuclear antigen Ki-67 (MIB-1). Malignant tumours negative for progesterone receptors proliferated at higher rates than progesterone receptor-positive tumours, suggesting that the progression towards malignancy in spontaneous mammary tumours is accompanied by a decrease in hormonal steroid dependency. Only one malignant tumour was positive for oestrogen receptors.