Cognitive functions in Parkinson's disease: Relation to disease severity and hallucination

作     者：Wakamori, Takaaki Agari, Takashi Yasuhara, Takao Kameda, Masahiro Kondo, Akihiko Shinko, Aiko Sasada, Susumu Sasaki, Tatsuya Furuta, Tomohisa Date, Isao 

作者机构：Okayama Univ Grad Sch Med Dent & Pharmaceut Sci Dept Neurol Surg Okayama 7008558 Japan Kibi Int Univ Dept Psychol Okayama Japan 

出 版 物：《PARKINSONISM & RELATED DISORDERS》 (帕金森氏病及有关疾患)

年 卷 期：2014年第20卷第4期

页      面：415-420页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：Japan Society for the Promotion of Science  JSPS  (25861277  26293323  26861151) 

主　　题：Parkinson's disease Cognitive functions Disease severity Hallucinations SPECT 

摘      要：Objective: We wished to relate severity of Parkinson s disease (PD) with cognitive function in relation to cerebral blood flow (CBF). Methods: Eighty-one consecutive PD patients were enrolled in this study. We used Mini-Mental State Examination (MMSE) and Wechsler Adult Intelligence Scale-Third edition (WAIS-III) to evaluate cognitive functions, and three-dimensional stereotactic ROI template (3DSRT) and Statistical Parametric Mapping (SPM) 8 to evaluate single photon emission CT (SPECT) recordings of regional CBF. Results: The mean MMSE score of PD patients was 27.4 +/- 2.4. The scores of most patients were higher than 23/30. On the other hand, the mean Full-scale IQ of PD patients was 88.4 +/- 17.3 in WAIS-III, which was lower than that of normal controls. In particular, visuospatial function score of most patients was lower. There was significant correlation between cognitive scores and Hoehn & Yahr stage and hallucinatory episodes. PD Patients with stage III and IV showed significant deterioration in cognitive functions compared to stage II patients. Analysis of CBF revealed relative reductions in perfusion in the cerebral cortex relative to that in normal control. SPM 8 showed that cognitive functions in PD patients were positively correlated with rCBF in the thalamus and cingulate gyrus. Conclusions: This is the study to demonstrate the cognitive impairments in PD patients using WAIS-III. Visuospatial dysfunction might be caused by decrease in rCBF in the parietal and occipital lobes and dorsolateral prefrontal cortex. The severity of cognitive impairments in PD patients was correlated with disease severity and hallucinatory episodes. (C) 2014 Elsevier Ltd. All rights reserved.