Inverse association between carotid intima-media thickness and the antioxidant lycopene in atherosclerosis

作     者：Gianetti, J Pedrinelli, R Petrucci, R Lazzerini, G De Caterina, M Bellomo, G De Caterina, R 

作者机构：CNR Inst Clin Physiol Lab Thrombosis & Vasc Res I-56100 Pisa Italy Univ Pisa Cardiothorac Dept Pisa Italy Univ Pisa Dept Radiol Pisa Italy Univ Naples Federico II Dept Clin Biochem Naples Italy A Avogadro Univ Eastern Piedmont Dept Med Sci Novara Italy Univ G DAnnunzio Chair Cardiol Chieti Italy 

出 版 物：《AMERICAN HEART JOURNAL》 (美国心脏杂志)

年 卷 期：2002年第143卷第3期

页      面：467-474页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：方差分析 抗氧化剂/分析 动脉硬化/血液 动脉硬化/病理学 生物学标记/血液 类胡萝卜素类/血液 颈动脉疾病/血液 颈动脉疾病/病理学 E选择素/血液 高血压/血液 胞间黏附分子1/血液 外周血管疾病/血液 外周血管疾病/病理学 泛醌/血液 血管细胞黏附分子1/血液 α生育酚/血液 β胡萝卜素/血液 γ生育酚/血液 女(雌)性 人类 男(雄)性 中年人 

摘      要：Background Antioxidants may prevent atherosclerosis by interfering with endothelial activation, which involves the expression of endothelial adhesion molecules. The aim of this study was to explore the relationship between plasma levels of some lipid-soluble antioxidants (gamma-tocopherol, gamma-tocopherol, lycopene, beta-carotene, and ubiquinone), carotid maximum intimamedia thickness (IMTmax), an index of atherosclerotic extension/severity, and soluble adhesion molecules (vascular cell adhesion molecule-1 [VCAM-1], intercellular adhesion molecule-1 [ICAM-1], and E-selectin), which are taken as a reflection of vascular cell expression of adhesion molecules. Methods We studied 11 healthy control subjects, 11 patients with uncomplicated hypertension (UH), and 11 patients with essential hypertension plus peripheral vascular disease (PVD) who were matched for age, sex, smoking habit, and body mass index. Results Patients with PVD had elevated IMTmax (2.7 [1.1-3.1 ] mm, median [range]) compared with both patients with UH(1.2 [0.8-2.4] mm) and control subjects (1.0 [0.6-2] mm). In patients with PVD, soluble (s)VCAM-1 and sICAM-1 were also significantly higher than in the 2 other categories. Plasma levels of lycopene had a trend toward lower values in patients with PVD compared with other groups (P = .13). A statistically significant correlation was found between lycopene and IMTmax (r = 0.42, P = .014) at univariate analysis, which persisted at multivariate analysis (P .05) and was independent of low-density lipoprotein cholesterol, creatinine clearance, and plasma insulin. Plasma lycopene did not significantly correlate with any of the soluble adhesion molecules tested. Conclusions We conclude that the inverse relationship of plasma lycopene with IMTmax is compatible with a protective role of this natural dietary antioxidant in atherosclerosis, although the mechanism of protection does not apparently involve a decrease in endothelial activation measured through solubl