Thiazides and bone

作     者：Sebastian, A 

作者机构：Univ Calif San Francisco Moffitt Hosp 1202 San Francisco CA 94143 USA Gen Clin Res Ctr San Francisco CA USA 

出 版 物：《AMERICAN JOURNAL OF MEDICINE》 (美国医学杂志)

年 卷 期：2000年第109卷第5期

页      面：429-430页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：钾/投药和剂量 钠氯同向转运体抑制剂/药理学 钠氯同向转运体抑制剂/治疗应用 

摘      要：During the past decade, the use of thiazide diuretics in the treatment of essential hypertension has decreased, despite their established antihypertensive efficacy, positive benefit in coronary heart disease, and low cost, and widespread recommendations for their use. That decrease may be, in part, the result of concern about their effects on lipid and carbohydrate metabolism, and, especially, by the promotion of newer classes of antihypertensive medications. However, thiazides have antihypertensive efficacy and cardiovascular benefit in doses below those that produce potentially adverse metabolic effects.