Conjunctival T-cell lymphoma caused by human T-cell lymphotrophic virus infection

作     者：Buggage, RR Smith, JA Shen, DF Chan, CC 

作者机构：NEI Immunol Lab NIH Bethesda MD 20892 USA 

出 版 物：《AMERICAN JOURNAL OF OPHTHALMOLOGY》 (美国眼科学杂志)

年 卷 期：2001年第131卷第3期

页      面：381-383页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：活组织检查 CD4阳性T淋巴细胞/病毒学 结膜肿瘤/诊断 结膜肿瘤/病毒学 DNA 肿瘤/分析 基因重排 T淋巴细胞/遗传学 基因 gag/遗传学 人类嗜T淋巴细胞病毒1型/遗传学 人类嗜T淋巴细胞病毒1型/分离和提纯 聚合酶链反应 受体 抗原 T细胞 γ-δ/遗传学 成年人 人类 男(雄)性 

摘      要：PURPOSE: To examine the cause of adult T-cell leukemia/ lymphoma. METHODS: We examined a conjunctival biopsy from a 29-year-old Jamaican man who developed bilateral conjunctival masses. Adult T-cell leukemia/lymphoma was diagnosed using routine histology, immunohistochemistry, electron microscopy, microdissection, and the polymerase chain reaction. RESULTS: Histopathologic examination revealed a conjunctival lymphoma. Clonality of the T-cell receptor gamma gene and human T-cell lymphotrophic virus gag gene were detected in the malignant cells. The demonstration of the human T-cell lymphotrophic virus gene and the rearrangement of the T-cell receptor gene in this neoplasm provide proof that human T-cell lymphotrophic virus is the cause of this conjunctival T-cell lymphoma, CONCLUSION: Human T-cell lymphotrophic virus is the cause of adult T-cell leukemia/lymphoma, an aggressive malignancy of CD4+ lymphocytes. (Am J Ophthalmol 2001;131:381-383, (C) 2001 by Elsevier Science Inc. All rights reserved.).