Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH

作     者：Weninger, SC Dunn, AJ Muglia, LJ Dikkes, P Miczek, KA Swiergiel, AH Berridge, CW Majzoub, JA 

作者机构：Childrens Hosp Div Endocrinol Boston MA 02115 USA Harvard Univ Sch Med Boston MA 02115 USA Childrens Hosp Howard Hughes Med Inst Program Neurosci Boston MA 02115 USA Childrens Hosp Dept Neurol Boston MA 02115 USA Louisiana State Univ Med Ctr Dept Pharmacol Shreveport LA 71130 USA Tufts Univ Dept Psychol Medford MA 02155 USA Univ Wisconsin Dept Psychol Madison WI 53706 USA 

出 版 物：《PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA》 (美国国家科学院汇刊)

年 卷 期：1999年第96卷第14期

页      面：8283-8288页

核心收录：

学科分类：07[理学] 08[工学] 

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摘      要：Corticotropin-releasing hormone (CRH) is a central regulator of the hormonal stress response, causing stimulation of corticotropin and glucocorticoid secretion. CRH is also widely believed to mediate stress-induced behaviors, implying a broader, integrative role for the hormone in the psychological stress response. Mice lacking the CRH gene exhibit normal stress-induced behavior that is specifically blocked by a CRH type 1 receptor antagonist. The other known mammalian ligand for CRH receptors is urocortin, Normal and CRH-deficient mice have an identical distribution of urocortin mRNA, which is confined to the region of the Edinger-Westphal nucleus, and is absent from regions known to mediate stress-related behaviors. Since the Edinger-Westphal nucleus is not known to project to any brain regions believed to play a role in anxiety-like behavior, an entirely different pathway must be postulated for urocortin in the Edinger-Westphal nucleus to mediate these behaviors in CRH-deficient mice. Alternatively, an unidentified CRH-like molecule other than CRH or urocortin, acting through the CRH receptors in brain regions believed to mediate stress-induced behaviors, may mediate the behavioral response to stress, either alone or in concert with CRH.