Negative-impedance ventilation and pressure support ventilation: A comparative study

作     者：Poon, CS Lebowitz, HH Sidney, DA Li, SX 

作者机构：Harvard-MIT Division of Health Sciences and Technology Rm 20A–126 Massachusetts Institute of Technology Cambridge MA 02 139 USA 

出 版 物：《RESPIRATION PHYSIOLOGY》 (呼吸生理学)

年 卷 期：1997年第108卷第2期

页      面：117-127页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 071003[理学-生理学] 

基　　金：NHLBI NIH HHS [HL45261  HL50614  HL52925] Funding Source: Medline 

主　　题：mechanical ventilation pressure support ventilation work of breathing respiratory muscle fatigue barotrauma hemodynamic instability airway obstruction 

摘      要：Negative impedance ventilation (NIV) is a novel mode of assisted mechanical ventilation (AMV) in which the pressure support is regulated to continuously track inspiratory flow and/or volume. In this study, we have evaluated the efficacies of NIV and inspiratory pressure support (IFS) ventilation in a model of central airway obstruction in six rabbits. For both AMV modes there was an inverse relationship between the intrinsic work of breathing and alveolar pressure. Compared to IFS, NIV was found to: (1) achieve the same degree of ventilatory unloading and similar level of pulmonary ventilation with considerably lower alveolar pressure;(2) better restore the normal tidal volume and respiratory frequency;(3) yield a shorter inspiratory duty cycle, thereby helping to rest the respiratory muscles and preclude intrinsic positive end-expiratory pressure. We conclude that NIV is more efficacious than IFS in negating airway obstruction and offers a better trade-off between the risks of respiratory muscle fatigue and pressure induced complications. (C) 1997 Elsevier Science B.V.