Distribution of Base Pair Repeats in Coding and Noncoding DNA Sequences

作     者：Nikolay V. Dokholyan Sergey V. Buldyrev Shlomo Havlin H. Eugene Stanley 

作者机构：Center for Polymer Studies Physics Department Boston University Boston Massachusetts 02215 Gonda-Goldschmied Center and Department of Physics Bar-Ilan University Ramat Gan 52900 Israel 

出 版 物：《Physical Review Letters》 (Phys Rev Lett)

年 卷 期：1997年第79卷第25期

页      面：5182-5182页

核心收录：

学科分类：07[理学] 0702[理学-物理学] 

主　　题：.DNA sequences leads fact dimeric long-range tails power-law dimers Volume Number coding and noncoding coding DNA DISTRIBUTION FUNCTIONS simple repeats 

摘      要：We analyze the histograms for the lengths of the 16 possible distinct repeats of identical dimers, known as dimeric tandem repeats, in DNA sequences. For coding regions, the probability of finding a repetitive sequence of ℓ copies of a particular dimer decreases exponentially as ℓ increases. For the noncoding regions, the distribution functions for most of the 16 dimers have long tails and can be approximated by power-law functions, while for coding DNA, they can be well fit by a first-order Markov process. We propose a model, based on known biophysical processes, which leads to the observed probability distribution functions for noncoding DNA. We argue that this difference in the shape of the distribution functions between coding and noncoding DNA arises from the fact that noncoding DNA is more tolerant to evolutionary mutational alterations than coding DNA.