Gene mapping by linkage and association analysis

作     者：March, RE 

作者机构：Astra Zeneca Res & Dev Genet Dept Macclesfield Cheshire England 

出 版 物：《MOLECULAR BIOTECHNOLOGY》 (分子生物技术)

年 卷 期：1999年第13卷第2期

页      面：113-122页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 0836[工学-生物工程] 

主　　题：human genetics genetic analysis linkage allelic association linkage disequilibrium computer program 

摘      要：Genetic analysis is used to map genes, including disease loci, to positions within the human genome. Linkage analysis depends on the co-segregation of a gene (locus) and a phenotype through a pedigree, while association analysis, or linkage disequilibrium mapping, depends on measuring deviation from the random occurrence of alleles in a haplotype in unrelated individuals or nuclear families. Complex computer programs may be used in both forms of analysis. In recent years most interest has focused on identifying genes involved in common, multifactorial diseases. Here I review some current and developing techniques of genetic analysis and give references to where further information can be obtained.