PHARMACOLOGICAL STUDY OF THE ONE SPIKE SPHERICAL NEURON PHENOTYPE IN <i>GYMNOTUS OMARORUM</i>

作     者：Nogueira, J. Caputi, A. A. 

作者机构：Inst Invest Biol Clemente Estable Dept Integrat & Computat Neurosci Montevideo Uruguay Univ Republica Fac Med Dept Histol & Embriol Montevideo Uruguay 

出 版 物：《NEUROSCIENCE》 (神经科学)

年 卷 期：2014年第258卷

页      面：347-354页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071003[理学-生理学] 

主　　题：intrinsic properties electroreception time coding low responsiveness window onset neuron single spiking 

摘      要：The intrinsic properties of spherical neurons play a fundamental role in the sensory processing of self-generated signals along a fast electrosensory pathway in electric fish. Previous results indicate that the spherical neuron s intrinsic properties depend mainly on the presence of two resonant currents that tend to clamp the voltage near the resting potential. Here we show that these are: a low-threshold potassium current blocked by 4-aminopyridine and a mixed cationic current blocked by cesium chloride. We also show that the low-threshold potassium current also causes the long refractory period, explaining the necessary properties that implement the dynamic filtering of the self-generated signals previously described. Comparative data from other fish and from the auditory system indicate that other single spiking onset neurons might differ in the channel repertoire observed in the spherical neurons of Gymnotus omarorum. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.