Three-dimensional object-oriented modeling of the stomach for the purpose of microprocessor-controlled functional stimulation

作     者：Rashev, PZ Bowes, KL Mintchev, MP 

作者机构：Univ Calgary Dept Elect & Comp Engn Calgary AB T2N 1N4 Canada Univ Alberta Dept Surg Edmonton AB T6G 2B7 Canada 

出 版 物：《IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE》 (IEEE Trans Inf Technol Biomed)

年 卷 期：2002年第6卷第4期

页      面：296-309页

核心收录：

基　　金：Natural Sciences and Engineering Research Council of Canada, NSERC Canada Foundation for Innovation, CFI 

主　　题：gastric stimulation gastrointestinal organs object-oriented modeling stomach 

摘      要：Three-dimensional (3-D) object-oriented models are needed for optimizing gastric electrical stimulation by performing virtual computer experiments. The aim of the study was to create a 3-D object-oriented electromechanical model of the stomach in vivo for the purpose of microprocessor controlled functional stimulation. The stomach was modeled using coaxial truncated conoids as objects. The strength of an external stimulating electric field generated by circumferentially implanted wire electrodes is related to artificial neurogenic and myogenic control of smooth muscle depolarization and contraction. Variation of the field strength modulates the frequency and concentration of acetylcholine release, as well as the transmembrane voltage of the muscle cells. Mechanical response of the stimulated tissue was quantified by two parametric functions of the electric field strength representing the relative contractile force and geometrical displacement of the gastric surface. Data from previously conducted canine experiments were used to test the validity of the model. The model was applied to simulate contractions with different positions, orientation and number of the circumferentially implanted stimulating electrodes. The model combined most of the existing theoretical and experimental findings concerning functional gastric stimulation and can be utilized as a flexible tool for virtual medical tests involving external high-frequency (50 Hz) neural stimulation.