Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov

作     者：Elsen, JM Amigues, Y Schelcher, F Ducrocq, V Andreoletti, O Eychenne, F Khang, JVT Poivey, JP Lantier, F Laplanche, JL 

作者机构：INRA SAGA F-31326 Auzeville France LABOGENA Jouy En Josas France Ecole Natl Vet Toulouse France INRA SGQA Jouy En Josas France INRA PII Nouzilly France Fac Pharm Biol Cellulaire Lab Paris France 

出 版 物：《ARCHIVES OF VIROLOGY》 (病毒学文献)

年 卷 期：1999年第144卷第3期

页      面：431-445页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 07[理学] 071005[理学-微生物学] 10[医学] 

主　　题：疾病暴发流行 法国/流行病学 疾病遗传易感性/遗传学 朊病毒/遗传学 羊瘙痒症/流行病学 羊瘙痒症/遗传学 羊瘙痒症/病理学 羊瘙痒症/传播 绵羊 动物 

摘      要：Information from a scrapie epidemic in a closed INRA Romanov flock is presented. Performances, pedigree, histopathological diagnoses and PrP genotypes were recorded from the beginning of the outbreak (in 1993). Between I st of April, 1993 and I st of May, 1997, 1015 animals were exposed to scrapie, and 304 died from this disease. A major influence of the polymorphisms at codons 136, 154 and 171 is shown, A(136)H(153)Q(171) allele carriers proving to be nearly as resistant as A(136)R(154)R(171) carriers. A possible relationship between gastrointestinal parasitism and scrapie is discussed. There is evidence of maternal transmission, with a risk;ratio for artificially fed lambs of 67 percent of the risk of lambs fed by their mother. Our results strongly suggest that resistant animals were not healthy carriers or at least were less infectious when comparing risk for lambs born to healthy dams either of resistant (risk = 0.431) or of susceptible (risk = 1.000) genotype.