An additive frailty model for correlated life times

作     者：Petersen, JH 

作者机构：Univ Copenhagen Dept Biostat DK-2200 Copenhagen N Denmark 

出 版 物：《BIOMETRICS》 (生物统计学)

年 卷 期：1998年第54卷第2期

页      面：646-661页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 0714[理学-统计学（可授理学、经济学学位）] 

主　　题：correlated frailty correlated life times EM algorithm genetic epidemiology heterogeneity semiparametric models 

摘      要：A frailty model for multivariate correlated life times is considered. The model both extends, in a rather straight-forward way, ordinary survival analysis with its emphasis on hazard modeling and incorporates well-known variance components models to account for the dependence between events of related individuals. Different approaches to estimation and inference are considered. An example from an ongoing study of genetic and environmental influences on premature death in adults serves to motivate and illustrate the model. Multivariate frailty models offer a conceptually simple and promising framework for analysis of correlated event times data, even if current knowledge is too sparse for such models to be tested critically.