The molecular basis for electrogenic computation in the brain: you can't step in the same river twice

作     者：Waxman, SG 

作者机构：Yale Univ Sch Med Dept Neurol New Haven CT 06510 USA Vet Affairs Med Ctr PVA EPVA Neurosci Res Ctr W Haven CT 06516 USA 

出 版 物：《MOLECULAR PSYCHIATRY》 (分子精神病学)

年 卷 期：1999年第4卷第3期

页      面：222-228页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：Eastern Paralyzed Veterans Association U.S. Department of Veterans Affairs, VA National Multiple Sclerosis Society 

主　　题：sodium channels action potential electrogenesis neural coding information processing CNS plasticity 

摘      要：Neural computation has classically been considered to be a process that depends, in large part, on the integration of excitatory and inhibitory synaptic signals by postsynaptic neurons;these cells generate sequences of action potentials that convey their messages, in turn, to still other neurons. We now appreciate that synaptic activity is a dynamic process that can be altered by mechanisms that include sprouting, pruning, facilitation, potentiation, and depression. But what about the electrogenic properties of neurons, ie the capability of these cells to generate all-or-non action potentials? Recent work indicates that the electrogenic machinery within neurons is also dynamic as a result of plasticity in the expression of sodium channels within the neuronal membrane. Molecular and functional remodeling of electrogenic membrane has been most extensively studied in developing and diseased neurons, but also occurs in the normal brain. The molecular plasticity of electrogenic membrane has important functional implications, since it can retune the neuron, changing its input-output relations.