Effect of cellular filamentation on adventurous and social gliding motility of <i>Myxococcus xanthus</i>

作     者：Sun, H Yang, ZM Shi, WY 

作者机构：Univ Calif Los Angeles Inst Mol Biol Los Angeles CA 90095 USA Univ Calif Los Angeles Sch Dent Los Angeles CA 90095 USA 

出 版 物：《PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA》 (美国国家科学院汇刊)

年 卷 期：1999年第96卷第26期

页      面：15178-15183页

核心收录：

学科分类：07[理学] 08[工学] 

基　　金：National Institute of Allergy and Infectious Diseases [T32AI007323] Funding Source: NIH RePORTER 

主　　题：细胞壁/药物作用 头孢氨苄/药理学 行走/生理学 黄色黏球菌/药物作用 黄色黏球菌/生理学 黄色黏球菌/超微结构 

摘      要：Filamentous bacterial cells often provide biological information that is not readily evident in normal-size cells, In this study, the effect of cellular filamentation on gliding motility of Myxococcus xanthus, a Gram-negative social bacterium, was investigated. Elongation of the cell body had different effects on adventurous and social motility of M. xanthus. The rate of A-motility was insensitive to cell-body elongation whereas the rate of S-motility was reduced dramatically as the cell body got longer, indicating that these two motility systems work in different ways. The study also showed that filamentous wild-type cells glide smoothly with relatively straight, long cell bodies. However, filamentous cells of certain social motility mutants showed zigzag, tangled cell bodies on a solid surface, apparently a result of a lack of coordination between different fragments within the filaments. Further genetic and biochemical analyses indicated that the uncoordinated movements of these mutant filaments were correlated with the absence of cell surface fibril materials, indicating a possible new function for fibrils.