Effects of endotoxemia on thrombopoiesis in men

作     者：Stohlawetz, P Folman, CC von dem Borne, AEGK Pernerstorfer, T Eichler, HG Panzer, S Jilma, B 

作者机构：Univ Vienna Sch Med Dept Clin Pharmacol Adhes Res Grp Elaborating Therapeut Vienna Austria Univ Vienna Sch Med Dept Transfus Med Clin Blood Grp Serol & Transfus Med Vienna Austria Univ Amsterdam Acad Med Ctr Dept Hematol Div Internal MedCent Lab Expt & Clin Immunol NL-1105 AZ Amsterdam Netherlands 

出 版 物：《THROMBOSIS AND HAEMOSTASIS》 (Thromb. Haemost.)

年 卷 期：1999年第81卷第4期

页      面：613-617页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

主　　题：血小板/化学 血小板/细胞学 C反应蛋白质/分析 细胞集合 双盲法 内毒素血症/病理生理学 血细胞生成/药物作用 白细胞介素6/血液 中性白细胞/细胞学 肽碎片/分析 血小板聚集/药物作用 血小板计数 血小板糖蛋白GPⅠb-Ⅸ复合物/分析 蛋白质前体/分析 凝血酶原/分析 血小板生成素/血液 成年人 人类 男(雄)性 

摘      要：Background. Febrile conditions are often associated with increased platelet turnover acid refractoriness to platelet transfusions, although several pyrogenic cytokines enhance thrombopoiesis. This study aimed to characterize the effects of experimental human endotoxemia on platelet turnover and thrombopoiesis. Methods. Endotoxin (4 ng/kg) was infused into 30 healthy men to study the regulation of thrombopoiesis in systemic human inflammation. Platelet counts, plasma thrombopoietin (TPO) and glycocalicin levels, and reticulated platelets (RP) were measured to evaluate the effect of acute endotoxemia on thrombopoiesis. Ten subjects received pretreatment with 1000 mg aspirin po, to evaluate possible effects of aspirin on platelet turnover, and ten subjects received paracetamol to control for effects of antipyresis. Results, Platelet counts dropped by about 15% (p 0.05). The number of circulating platelet-neutrophil aggregates increased more than 100% at 6 h (p 0.001). Neither aspirin nor paracetamol affected changes in any of the parameters measured. Conclusion. Low grade endotoxemia induces a rapid fall of platelet counts, which is followed by an early increase in reticulated platelets and TPO levels but not of glycocalicin levels. Finally peripheral platelet counts increase several days after LPS infusion.