Impaired reaching and grasping after focal inactivation of globus pallidus pars interna in the monkey

作     者：Wenger, KK Musch, KL Mink, JW 

作者机构：Washington Univ Sch Med Dept Neurol St Louis MO 63110 USA Washington Univ Sch Med Program Phys Therapy St Louis MO 63110 USA St Louis Childrens Hosp St Louis MO 63110 USA 

出 版 物：《JOURNAL OF NEUROPHYSIOLOGY》 (神经生理学杂志)

年 卷 期：1999年第82卷第5期

页      面：2049-2060页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071003[理学-生理学] 

基　　金：NINDS NIH HHS [T32NS07027  K08NS01808] Funding Source: Medline 

主　　题：基底神经节/生理学 GABA激动剂/药理学 苍白球/药物作用 苍白球/生理学 握力/生理学 猕猴 运动活动/药物作用 运动活动/生理学 蝇蕈醇/药理学 精神运动性行为/药物作用 精神运动性行为/生理学 反应时间/药物作用 受体 GABA-A/生理学 动物 男(雄)性 

摘      要：The purpose of this study was to test the hypothesis that the basal ganglia output from globus pallidus pars interna (GPi) contributes to inhibition of competing motor patterns to prevent them from interfering with a volitional movement. To test this hypothesis, the kinematics of a natural reach, grasp, and retrieval task were measured in the monkey before and after focal inactivation in GPi with the GABA(A) agonist muscimol. Two rhesus monkeys were trained to reach in a parasagittal plane to grasp a l-cm cube of apple and retrieve it. Reflective markers were applied to the shoulder, elbow, wrist, and index finger. Movements were videotaped at 60 fields/s, digitized, and analyzed off-line. In each session the monkey performed 12-15 reaches before and 12-15 reaches after injection of 0.5 mu l of 8.8 mM muscimol. Muscimol was injected into 22 separate locations in the arm area of GPi. Inactivation of the GPi with muscimol produced movement deficits in a reach-grasp-retrieve task that can be summarized as follows: I) decreased peak wrist velocity during the reach to target;2) decreased elbow and shoulder angular velocities, with elbow angular velocity relatively more impaired than shoulder angular velocity;resulting in 3) higher maximum vertical wrist and index finger positions at the apex of the reach;4) prolonged latency from the end of the reach to the completion of grasp;and 5) less impairment of retrieval than reach, with inactivation at the majority of sites causing no impairment and some actually speeding up retrieval despite slow reaching. The results of this study show that reaching movements are impaired in a specific way after focal inactivation of GPi in previously normal monkeys. The slowing of the reach with normal (or fast) retrieval suggests that there is difficulty inhibiting the posture holding mechanisms that were active before the reach, but that assist the retrieval. The nature of the impairment supports the hypothesis that GPi lesions disrupt th