Inhibition of gastric emptying by triterpene saponin, momordin Ic, in mice: Roles of blood glucose, capsaicin-sensitive sensory nerves, and central nervous system

作     者：Matsuda, H Li, Y Yamahara, J Yoshikawa, M 

作者机构：Kyoto Pharmaceut Univ Yamashima Ku Kyoto 6078414 Japan 

出 版 物：《JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS》 (药理学与实验治疗学杂志)

年 卷 期：1999年第289卷第2期

页      面：729-734页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：血糖/代谢 辣椒辣素/药理学 中枢神经系统/药物作用 抑制 化学性 糖尿病 实验性/代谢 糖尿病 实验性/病理生理学 膳食 胃排空/药物作用 降血糖药/化学 降血糖药/药理学 神经元 传入/药物作用 齐墩果酸/类似物和衍生物 齐墩果酸/化学 齐墩果酸/药理学 交感神经系统/药物作用 动物 男(雄)性 小鼠 

摘      要：The roles of capsaicin-sensitive sensory nerves and the central nervous system in the inhibitory effect of momordin Ic, a principal saponin constituent in various Chinese and Japanese herbal medicines, such as the fruit of Kochia scoparia (L) SCHRAD., on gastric emptying were investigated in nonnutrient meal- or nutrient meal-loaded mice. Momordin Ic (12.5-50 mg/kg) significantly inhibited gastric emptying in 1.5% carboxymethyl cellulose sodium salt test meal-loaded mice by 8.4%-60.6%, 40% glucose test meal-loaded mice by 42.8% (50 mg/kg), milk test meal-loaded mice by 36.4% (50 mg/kg), and 60% ethanol test meal-loaded mice by 37.2% (50 mg/kg). The inhibitory effect on the gastric emptying in 1.5% carboxymethyl cellulose sodium salt test meal-loaded mice was potentiated by glucose (2 g/kg, i.v. or 5 g/kg, i.p.), but markedly attenuated by pretreatment with alloxan (50 mg/kg, i.v.) and streptozotocin (100 mg/kg, i.v.), in which the activity of sympathetic nervous system was decreased, or by insulin (1 or 3 U/kg, s.c.). The effect of insulin (1 U/kg) was markedly reduced by glucose (2 g/kg, i.v.), which can directly nourish the brain, but not by fructose (2 g/kg, i.v.), which cannot be used by the brain. The effect of momordin Ic was also attenuated by pretreatment with capsaicin (75 mg/kg in total, s.c.). These results suggest that the inhibition of gastric emptying by momordin Ic is relative to serum glucose and, at least in part, mediated by capsaicin-sensitive sensory nerves and the central nervous system.