Correlation between human papillomavirus-associated cervical cancer and p53 codon 72 arginine/proline polymorphism

作     者：Tachezy, R Mikysková, I Saláková, M Van Ranst, M 

作者机构：Univ Leuven Sch Med Rega InstLab Virol Dept Microbiol & Immunol B-3000 Louvain Belgium Univ Leuven Sch Med Univ Hosp Leuven B-3000 Louvain Belgium Inst Hematol & Blood Transfus Dept Expt Virol CR-12820 Prague Czech Republic 

出 版 物：《HUMAN GENETICS》 (人类遗传学)

年 卷 期：1999年第105卷第6期

页      面：564-566页

核心收录：

学科分类：0710[理学-生物学] 0303[法学-社会学] 03[法学] 030303[法学-人类学] 

基　　金：International Union Against Cancer, UICC, (ICRETT/602/1997) Ministerio de Sanidad, Consumo y Bienestar Social, MISAN, (4070-3) Grantová Agentura České Republiky, GA ČR, (3112/94/0886) 

主　　题：氨基酸取代 精氨酸/遗传学 供血者 密码子 捷克共和国 DNA突变分析 基因型 乳头状瘤病毒科 乳头状瘤病毒感染/并发症 聚合酶链反应 多态现象 遗传 脯氨酸/遗传学 肿瘤抑制蛋白质p53/遗传学 肿瘤病毒感染/并发症 宫颈肿瘤/遗传学 宫颈肿瘤/病毒学 成年人 老年人 老年人 80以上 女(雌)性 人类 中年人 

摘      要：High-risk mucosal human papillomaviruses encode an EG oncoprotein, which binds the cellular p53 tumor suppressor protein, thereby marking it for degradation through the ubiquitin-mediated pathway. A common p53 polymorphism at codon-72 of exon 4 results in translation to either arginine or proline. Recently reported: data suggested an increased susceptibility to E6/ubiquitin-mediated degradation of the Arg72-p53 isoform and an overrepresentation of the homozygous Arg72-p53 genotype in cervical cancer patients. We have analyzed this polymorphism in a larger series of patients with cervical cancer and in controls in the Czech Republic. We found no statistically significant differences between the codon-72 p53 genotypes of cervical cancer patients and the control women. Based on these results, it is unlikely that Arg72-p53 is associated with an increased risk for human papillomavirus-associated cervical tumor development in Czech women.