Characterization of a bacteriocin-like substance produced by a vaginal <i>Lactobacillus salivarius</i> strain

作     者：Ocaña, VS Holgado, AAPD Nader-Macías, ME 

作者机构：CERELA RA-4000 San Miguel De Tucuman Tucuman Argentina Univ Nacl Tucuman Fac Bioquim Quim & Farm RA-4000 San Miguel De Tucuman Tucuman Argentina 

出 版 物：《APPLIED AND ENVIRONMENTAL MICROBIOLOGY》 (应用与环境微生物学)

年 卷 期：1999年第65卷第12期

页      面：5631-5635页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 07[理学] 0836[工学-生物工程] 071005[理学-微生物学] 10[医学] 

主　　题：细菌素类/生物合成 细菌素类/药理学 念珠菌属/药物作用 抗药性 微生物 肠球菌 粪/药物作用 肠球菌 屎/药物作用 动力学 乳杆菌属/生长和发育 乳杆菌属/分离和提纯 乳杆菌属/代谢 微生物敏感性试验 奈瑟球菌 淋病/药物作用 阴道/微生物学 女(雌)性 人类 

摘      要：A novel bacteriocin-like substance produced by vaginal Lactobacillus salivarius subsp. salivarius CRL 1328 with activity against Enterococcus faecalis, Enterococcus faecium, and Neisseria gonorrhoeae was characterized, The highest level of production of this heat-resistant peptide or protein occurred during the late exponential phase. Its mode of action was shown to be bactericidal. L. salivarius subsp. salivarius CRL 1328 could be used for the design of a probiotic to prevent urogenital infections.