Occupational hazard evaluation of p-bromobenzyl bromide from tests for genotoxicity

作     者：Sargent, EV Sina, JF Barnum, JE Storer, RD Johnson, TE Galloway, SM Prato, MG Kirsten, NN Naumann, BD 

作者机构：Merck & Co Inc Toxicol & Environm Hlth Whitehouse Stn NJ 08889 USA Merck Res Labs Genet & Cellular Toxicol W Point PA 19486 USA 

出 版 物：《DRUG AND CHEMICAL TOXICOLOGY》 (药物与化学毒理学)

年 卷 期：1999年第22卷第4期

页      面：583-593页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 

主　　题：苄基化合物/毒性 CHO细胞/药物作用 染色体畸变 染色体/药物作用 仓鼠亚科 仓鼠属 DNA/化学 DNA/药物作用 DNA损伤/药物作用 肝/药物作用 诱变力试验 诱变剂/毒性 职业暴露 大鼠 Sprague-Dawley 鼠伤寒沙门菌/药物作用 鼠伤寒沙门菌/遗传学 动物 男(雄)性 大鼠 

摘      要：As part of an occupational hazard evaluation, p-bromobenzyl bromide (p-BBB) was evaluated for genotoxic activity in the Ames microbial mutagenicity assay, the alkaline elution assay for DNA strand breaks in rat hepatocytes and the in vitro chromosome aberration assay in Chinese hamster ovary cells. The compound produced equivocal results in the microbial mutagenicity assay but was negative in the alkaline elution assay for DNA strand breaks in rat hepatocytes. The compound produced weakly positive results in the in vitro chromosome aberration assay. There was substantial cytotoxicity in all three assays. It is concluded that p-BBB is weakly genotoxic.