Induction of NMDA receptor-dependent long-term depression in visual cortex does not require metabotropic glutamate receptors

作     者：Sawtell, NB Huber, KM Roder, JC Bear, MF 

作者机构：Brown Univ Dept Neurosci Howard Hughes Med Inst Providence RI 02912 USA Mt Sinai Hosp Samuel Lunenfeld Res Inst Program Dev & Fetal Hlth Toronto ON M5G 1X5 Canada Univ Toronto Dept Mol & Med Genet Toronto ON M5S 1A8 Canada 

出 版 物：《JOURNAL OF NEUROPHYSIOLOGY》 (神经生理学杂志)

年 卷 期：1999年第82卷第6期

页      面：3594-3597页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071003[理学-生理学] 

主　　题：氨基酸类/药理学 环亮氨酸/类似物和衍生物 环亮氨酸/药理学 抑制 化学性 兴奋性氨基酸拮抗剂/药理学 水解作用 甲氧基羟基苯乙二醇/类似物和衍生物 甲氧基羟基苯乙二醇/药理学 小鼠 基因敲除 神经元可塑性/药物作用 神经元可塑性/生理学 磷脂酰肌醇类/代谢 受体 亲代谢性谷氨酸盐/激动剂 受体 亲代谢性谷氨酸盐/拮抗剂和抑制剂 受体 亲代谢性谷氨酸盐/生理学 受体 N-甲基-D-天冬氨酸/拮抗剂和抑制剂 受体 N-甲基-D-天冬氨酸/遗传学 受体 N-甲基-D-天冬氨酸/生理学 突触体/药物作用 突触体/代谢 视皮质/药物作用 视皮质/生理学 呫吨类/药理学 动物 小鼠 大鼠 

摘      要：We tested the role of group I mGluRs in the induction of long-term depression (LTD) in the visual cortex, using the novel mGluR antagonist LY341495 and mice lacking mGluR5, the predominant phosphoinositide (PI)-linked mGluR in the visual cortex. We find that LY341495 is a potent blocker of glutamate-stimulated PI hydrolysis in visual cortical synaptoneurosomes, and that it effectively antagonizes the actions of the mGluR agonist 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (ACPD) on synaptic transmission in visual cortical slices. However, LY341495 has no effect on the induction of LTD by low-frequency stimulation. Furthermore, mice lacking mGluR5 show normal NMDA receptor-dependent LTD. These results indicate that group I mGluR activation is not required for the induction of NMDA receptor-dependent LTD in the visual cortex.