Antibacterial peptide from <i>H-pylori</i>

作     者：Pütsep, K Brändén, CI Boman, HG Normark, S 

作者机构：Karolinska Inst Ctr Microbiol & Tumor Biol SE-17177 Stockholm Sweden 

出 版 物：《NATURE》 (Nature)

年 卷 期：1999年第398卷第6729期

页      面：671-672页

核心收录：

学科分类：07[理学] 08[工学] 

主　　题：氨基酸序列 抗菌药/化学 抗菌药/分离和提纯 抗菌药/药理学 芽孢杆菌 巨大/药物作用 细菌蛋白质类/化学 细菌蛋白质类/分离和提纯 细菌蛋白质类/药理学 大肠杆菌/药物作用 螺杆菌感染 螺杆菌 幽门/化学 肽类 核糖体蛋白质类/分离和提纯 胃/微生物学 人类 

摘      要：Colonization of the human stomach by the bacterium Helicobacter pylori is a predisposing factor for gastrointestinal illnesses such as gastritis and peptic ulcers. But most infections are asymptomatic, and it has recently been suggested that H. pylori may actually have beneficial effects on infected carriers who are heavily exposed to other gastrointestinal pathogens. We find that H. pylori possesses antibacterial activity to which it is itself resistant. We have traced this activity to cecropin-like amino-terminal peptides derived from the ribosomal protein L1 (RpL1).