Dopamine D₃ receptors modulate evoked dopamine release from slices of rat nucleus accumbens via muscarinic receptors, but not from the striatum

作     者：Yamada, S Harano, M Annoh, N Tanaka, M 

作者机构：Kurume Univ Sch Med Inst Brain Dis Kurume Fukuoka 8300011 Japan 

出 版 物：《JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS》 (药理学与实验治疗学杂志)

年 卷 期：1999年第291卷第3期

页      面：994-998页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

主　　题：8-羟-2-(二-n-丙胺)四氢萘/类似物和衍生物 8-羟-2-(二-n-丙胺)四氢萘/药理学 多巴胺/代谢 多巴胺激动剂/药理学 多巴胺拮抗剂/药理学 电刺激 氟哌啶醇/药理学 茚满类/药理学 毒蕈碱拮抗剂/药理学 新纹状体/药物作用 新纹状体/代谢 新纹状体/生理学 伏核/药物作用 伏核/代谢 伏核/生理学 哌仑西平/药理学 喹吡罗/药理学 大鼠 Wistar 受体 多巴胺D2/药物作用 受体 多巴胺D3 受体 毒蕈碱/药物作用 动物 男(雄)性 大鼠 

摘      要：It is not clear whether dopamine D-3 receptor contributes to the regional difference in dopamine antagonist-induced increase in the evoked dopamine release from the nucleus accumbens and striatum. We investigated the regional differences in augmentation of electrically evoked dopamine release induced by preferential dopamine D-2 or D-3 receptor antagonists from slices of the rat striatum and nucleus accumbens. Haloperidol, a preferential dopamine D-2 receptor antagonist, enhanced the evoked dopamine release from both the striatum and nucleus accumbens. Preferential dopamine D-3 antagonists, cis-(+)-(1S,2R)-5-methoxy-1-methyl-2-(di-n-propylamino)tetralin HCl [(+)-UH232] and 5,6-dimethoxy-2-(di-n-propylamine)indan (U-99194A) resulted in a greater increase in the evoked dopamine released from the nucleus accumbens compared with that from the striatum. Moreover, U-99194A attenuated the quinpirole-induced reduction of evoked dopamine release from the nucleus accumbens but not from the striatum. When slices were superfused with pirenzepine, a muscarinic receptor antagonist, the increase in the evoked dopamine release by (+)-UH232 or U-99194A was reduced in the nucleus accumbens to the same level as that in the striatum. Our results indicate that the preferential D-3 receptor antagonists-induced increase in evoked dopamine release is probably mediated by the cholinergic system in the nucleus accumbens, which contains more postsynaptic dopamine D-3 receptors than the striatum.