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作者机构:Hebrew Univ Jerusalem Inst Life Sci Dept Cell & Anim Biol IL-91904 Jerusalem Israel Newton Wellesley Hosp Div Neurosurg Wellesley Hills MA 02481 USA Karolinska Inst Dept Neurosci S-17177 Stockholm Sweden
出 版 物:《JOURNAL OF NEUROCYTOLOGY》 (脑细胞生物学杂志)
年 卷 期:1999年第28卷第9期
页 面:743-761页
核心收录:
学科分类:0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071003[理学-生理学]
基 金:German-Israel Foundation for Research and Development Israel Absorption Ministry/Gileadi Foundation German-Israeli Foundation for Scientific Research and Development, GIF United States-Israel Binational Science Foundation, BSF Hebrew University of Jerusalem, HUJI
主 题:轴突切断术 活组织检查 细胞间通讯/生理学 神经节 脊/病理学 神经节 脊/超微结构 显微镜检查 电子 神经痛/病理学 神经痛/病理生理学 神经胶质/细胞学 神经元 传入/化学 神经元 传入/酶学 神经元 传入/超微结构 大鼠 Wistar 受体 肾上腺素能α2/分析 坐骨神经/损伤 酪氨酸单氧化酶/分析 成年人 动物 女(雌)性 人类 男(雄)性 中年人 大鼠
摘 要:Tyrosine hydroxylase immunocytochemistry was used to reveal the sympathetic postganglionic axons that sprout to form basket-like skeins around the somata of some primary sensory neurons in dorsal root ganglia (DRGs) following sciatic nerve injury. Ultrastructural observations in rats revealed that these sprouts grow on the surface of glial lamellae that form on the neurons. Sciatic nerve injury triggers glial cell proliferation in the DRG, and the formation of multilamellar pericellular onion bulb sheaths, primarily around large diameter DRG neurons. We infer that these glia participate in the sprouting process by releasing neurotrophins and expressing growth supportive cell surface molecules. Many DRG cell somata, and their axons in intact nerves and nerve end neuromas, express alpha 2A adrenoreceptors intracytoplasmically and on their membrane surface. However, sympathetic axons never make direct contacts with the soma membrane. The functional coupling known to occur between sympathetic efferents and DRG neurons must therefore be mediated by the diffusion of neurotransmitter molecules in the extracellular space. Sympathetic basket-skeins were observed in DRGs removed from human neuropathic pain patients, but the possibility of a functional relation between these structures and sensory symptoms remains speculative.