Enhanced absorption of pour-on ivermectin formulation in rats by co-administration of the multidrug-resistant-reversing agent verapamil

作     者：Alvinerie, M Dupuy, J Eeckhoutte, C Sutra, JF 

作者机构：INRA Lab Pharmacol Toxicol F-31931 Toulouse France 

出 版 物：《PARASITOLOGY RESEARCH》 (寄生虫学研究)

年 卷 期：1999年第85卷第11期

页      面：920-922页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

主　　题：吸收 投药 皮肤 抗蠕虫药/投药和剂量 抗蠕虫药/药代动力学 抗药性 多药 伊维菌素/投药和剂量 伊维菌素/药代动力学 大鼠 Sprague-Dawley 皮肤吸收 维拉帕米/投药和剂量 动物 大鼠 

摘      要：The effect of verapamil, a multidrug-resistance (Mdr)-reversing agent on the absorption of a pour-on formulation of ivermectin was evaluated in rats. Absorption of ivermectin was effectively enhanced (40%) by the presence of verapamil, suggesting that absorption of ivermectin involves Mdr-P-glycoprotein and that verapamil should act as a competitive inhibitor for the transport and extrusion of ivermectin by P-glycoprotein. This hypothesis is consistent with other studies describing verapamil as a blocking agent of P-glycoprotein involved in the efflux of ivermectin in a resistant strain of Haemonchus contortus.