DNA-Polymorphisms and plasma levels of vascular disease risk factors in Greenland Inuit - Is there a relation with the low risk of cardiovascular disease in the Inuit?

作     者：de Maat, MPM Bladbjerg, EM Johansen, LG de Knijff, P Gram, J Kluft, C Jespersen, J 

作者机构：TNO PG Gaubius Lab NL-2301 CE Leiden Netherlands Ribe Cty Hosp Dept Clin Biochem Esbjerg Denmark Univ So Denmark Dept Thrombosis Res Esbjerg Denmark 

出 版 物：《THROMBOSIS AND HAEMOSTASIS》 (Thromb. Haemost.)

年 卷 期：1999年第81卷第4期

页      面：547-552页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

主　　题：等位基因 血管紧张素原/遗传学 抗纤维蛋白溶解药/药理学 心血管疾病/流行病学 DNA/血液 DNA/遗传学 丹麦/流行病学 纤维蛋白纤维蛋白原降解物/遗传学 格陵兰/流行病学 伊努/遗传学 多态现象 遗传 危险因素 血管疾病/血液 血管疾病/人种学 血管疾病/遗传学 成年人 女(雌)性 人类 男(雄)性 

摘      要：Greenland Inuit are a population with a low risk of cardiovascular disease. Recently, we stated that frequencies of potentially high risk alleles of the apolipoproteins, fibrinogen, factor V, glycoprotein IIIa and factor VII (FVII) genes have different allele frequencies in the Inuit when compared with Caucasian populations. We have extended this study and evaluated whether or not this was also true for the genetic polymorphisms of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), angiotensin-converting enzyme (ACE) and angiotensinogen in a group of 133 Greenland Inuit, aged 30-34 y. In addition, we compared the plasma levels of these factors and those of C-reactive protein (CRP) and D-Dimer in Inuit and in Danes, comparable for age and gender. Frequencies (f) were assessed of the alleles that are known as the potential high risk alleles in Caucasians. In the Inuit, the f(insertion allele) of the t-PA intron8ins311 polymorphism was 0.37 (CI 0.32-0.43), the f(4G allele) of the PAI-1 promoter polymorphism was 0.88 (CI 0.83-0.91), the f(deletion allele) of the ACE intron16ins287 polymorphism was 0.40 (CI 0.33-0.47) and the f(M-allele) of the angiotensinogen M/T353 polymorphism was 0.30 (CI 0.25-0.38). As for fibrinogen and FVII polymorphisms, these frequencies are all significantly different from what is reported for Caucasian populations. In the Inuit, plasma levels of fibrinogen and D-Dimer were higher than in the Danes, the PAI-1 levels were lower and FVII, t-PA and CRP levels were comparable. The observed allele frequencies of the polymorphisms of t-PA, fibrinogen, FVII, ACE, angiotensinogen and the plasma levels of PAI-1 and D-Dimer were in accordance with the low CVD risk in the Inuit, considering the observed associations between these measures and CVD risk in Caucasian populations, but for other measures this was not the case (allele frequencies of the PAI-1 polymorphism, and plasma levels of fibrinogen, FVII and t-PA). In con