Genetic Characterization of Fowl Adenovirus Strains Isolated from Poultry in China

作     者：Zhang, Hewei Jin, Wenjie Ding, Ke Cheng, Xiangchao Sun, Yaru Wang, Jianke Cheng, Shipeng Wu, Hua Zhang, Chunjie 

作者机构：State Key Laboratory for Molecular Biology of Special Economic Animals Institute of Special Economic Animal and Plant Sciences Chinese Academy of Agricultural Sciences 130112 China Key Lab of Animal Disease and Public Health Henan University of Science and Technology Luoyang 471023 China College of Veterinary Yangzhou University 225002 China 

出 版 物：《Avian Diseases》 (Avian Dis.)

年 卷 期：2017年第61卷第3期

页      面：341-346页

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 0905[农学-畜牧学] 0906[农学-兽医学] 09[农学] 0836[工学-生物工程] 

基　　金：Institute of Special Economic Animal and Plant Sciences of CAAS Key Lab of Animal Disease and Public Health Henan University of Science and Technology, HUST 

主　　题：fowl adenoviruses hexon gene isolation phylogenetic analysis 

摘      要：SUMMARY Fowl adenoviruses (FAdVs) infect chickens worldwide, resulting in global economic losses in the poultry industry. We examined the strains present in chickens in regions of China where infections are particularly prevalent. Fifteen FAdV strains were successfully isolated in the field. The L1 loop region of the hexon gene was sequenced to genetically identify the FAdV isolates. By comparing these sequences to adenovirus reference strain sequences using phylogenetics, 15 adenovirus strains were found to cluster into two distinct species. One cluster containing 12 strains belonged to the fowl adenoviruses C species and serotyped as FAdV-4. The other cluster containing three strains belonged to the fowl adenoviruses E species and serotyped as FAdV-10. To our knowledge, this is the first report of the existence of fowl adenoviruses E in China. Furthermore, at least two types of fowl adenovirus strains are predominant among poultry in China. Cumulatively, this study helps lays the groundwork for future research on the pathogenicity and potential treatment measures for FAdV infections in chickens.