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作者机构:SWEDISH UNIV AGR SCI DEPT CHEM & MOLEC BIOL S-75007 UPPSALA SWEDEN
出 版 物:《MUTATION RESEARCH》 (突变研究-突变原理与分子结构)
年 卷 期:1985年第144卷第3期
页 面:131-136页
核心收录:
学科分类:0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 09[农学]
基 金:Swedish Cancer Foundations (1824-B85-03x)
主 题:Glu-P-1 6-methyl-5 H -dipyrido[1,2- a :3′,2′- d ]-imidazol-2-amine, 67730-11- Glu-P-2 5 H -dipyrido[1,2- a :3′,2′- d ]imidazol-2-amine, 67730-10-3 IQ 3-methyl-3 H -imidazo[4,5- f ]quinolin-2-amine, 76180-96-6 MeIQ 3,4-dimethyl-3 H -imidazo[4,5- f ]quinolin-2-amine, 77094-11-2 MeIQx 3,8-dimethyl-3 H -imidazo[4,5- f ]quinoxalin-2-amine, 77500-04-0 “7MeIQx” 3,7-dimethyl-3 H -imidazo[4,5- f ]quinoxalin-2-amine, 78411-56-0 Trp-P-1 1,4-dimethyl-5 H -pyrido[4,3- b ]indol-3-amine, 62450-06-0 Trp-P-2 1-methyl-5 H -pyrido[4,3- b ]-indol-3-amine 62450-07-1
摘 要:The title compounds were synthesized and tested for mutagenicity on Salmonella typhimurium TA98 in the presence of S9 mix. All test compounds showed lower activity than their respective 3-methyl analogues (IQ compounds). The replacement of the 3-methyl by an ethyl group should not alter the chemistry of these compouds;hence their lower mutagenic activity could merely be of steric origin.