Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects

作     者：Qihao Wu Bastien Nay Min Yang Yeke Ni Hong Wang Ligong Yao Xuwen Li 

作者机构：State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences College of Pharmaceutical Science Zhejiang University of Technology Laboratoire de Synthèse Organique UMR 7652 CNRS Ecole Polytechnique Université Paris-Saclay 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2019年第9卷第2期

页      面：237-257页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (NSFC, Nos. 41676073, 81520108028) the National Natural Science Foundation of China /Centre National de la Recherché Scientifique (NSFC/CNRS) joint project (No. 81811530284) "Youth Innovation Promotion Association" (No. 2016258) from Chinese Academy of Sciences the SA-SIBS Scholarship Program the National Key Research and Development Program (2017YFE0103100) 

主　　题：Marine natural products Stelletta sponge Isolation Total synthesis Biological activity Marine drug leads 

摘      要：Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated Stelletta sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018.