ELECTROPHYSIOLOGIC EFFECTS OF ISOPROTERENOL ON CARDIAC CONDUCTION SYSTEM IN MAN

作     者：VARGAS, G AKHTAR, M DAMATO, AN 

作者机构：US PHS HOSP CARDIOPULM LAB HOSP Staten Isl NY 10304 USA 

出 版 物：《AMERICAN HEART JOURNAL》 (美国心脏杂志)

年 卷 期：1975年第90卷第1期

页      面：25-34页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：房室结/药物作用 希氏束/药物作用 电刺激 心电描记术 心脏导管插入术 心脏传导系统/药物作用 异丙肾上腺素/药理学 心脏起搏器 人工 浦肯野纤维/药物作用 不应期 电生理学/药物作用 成年人 老年人 女(雌)性 人类 男(雄)性 中年人 

摘      要：The effects of isoproterenol (ISOP) on the functional properties of the A-V conduction system were studied in 16 patients using Hisbundle recordings and the atrial extrastimulus technique. In all patients, ISOP at an infusion rate of 1 mcg. per minute resulted in sinus acceleration and enhancement of A-V nodal conduction, but had no effect on His-Purkinje conduction time. ISOP significantly decreased both functional and effective refractory periods of the A-V node. The relative refractory period of the His-Purkinje system decreased by a small amount in five patients in whom the parameter could be compared before and after the drug.