FORMATION OF 2-AMINO-3,8-DIMETHYLIMIDAZO[4,5-F]QUINOXALINE IN A MODEL SYSTEM BY HEATING CREATININE, GLYCINE AND GLUCOSE

作     者：JAGERSTAD, M OLSSON, K GRIVAS, S NEGISHI, C WAKABAYASHI, K TSUDA, M SATO, S SUGIMURA, T 

作者机构：UNIV LUND CTR CHEM DEPT NUTR S-22007 LUND 7 SWEDEN SWEDISH UNIV AGR SCI DEPT CHEM & MOLEC BIOL S-75007 UPPSALA SWEDEN NATL CANC CTR RES CTR DIV BIOCHEM CHUO KU TOKYO 104 JAPAN 

出 版 物：《MUTATION RESEARCH》 (突变研究－突变原理与分子结构)

年 卷 期：1984年第126卷第3期

页      面：239-244页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 09[农学] 

基　　金：Marabou Foundation Ministry of Education, Culture, Sports, Science and Technology, MEXT Ministry of Health and Welfare, MOHW 

主　　题：Trp-P-1 3-amino1,4-dimethyl-5 H -pyrido[4,3- b ]indole 62450-06-0 Trp-P2 3-amino-1-methyl-5 H -pyrido[4,3- b ]indole, 62450-07-1 Glu-P-1 2-amino-6-methyldipyrido[1,2- a :3′,2′- d ]imidazole, 67730-11-4 Glu-P-2 2-aminodipyrido[1,3- a :3′,2′- d ]imidazole, 67730-10-3 Orn-P-1 4-amino-6-methyl-1 H -2,5,10,10b-tetraazafluoranthene, 78859-36-6 Phe-P-1 2-amino-5-phenylpyridine, 33421-40-8 AαC 2-amino-9 H -pyrido[2,3- b ]indole, 26148-68-5 MeAαC 2-amino-3-methyl-9 H -pyrido[2,3- b ]indole, 68006-83-7 IQ 2-amino-3-methylimidaza[4,5- f ]quinoline, 76180-96-6 MeIQ 2-amino-3,4-dimethylimidazo[4,5- f ]quinoline, 77094-11-2 MeIQx 2-amino-3,8-dimethylimidazo[4,5- f ]quinoxaline, 77500-04-0 HPLC high performance liquid chromatography 

摘      要：A mixture of creatinine, glucose and Gly was heated in diethylene glycol containing 14% water for 2 h at ***. C, and the mutagens formed were purified by XAD-2 column chromatography, acid-base partition. Sephadex LH-20 column chromatography, blue cotton treatment and HPLC [high performance liquid chromatography]. Two mutagenic substances were isolated by HPLC. The major mutagen was identified by its UV absorption and mass and NMR spectra as 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, which was originally isolated from fried beef. The idea that creatinine, amino acids and sugars present in meat are precursors in the formation of the mutagenic imidazoquinoxaline derivative is supported.