High prevalence of herpes simplex virus type 2 in acute retinal necrosis syndrome associated with herpes simplex virus in Japan

作     者：Itoh, N Matsumura, N Ogi, A Nishide, T Imai, Y Kanai, H Ohno, S 

作者机构：Yokohama City Univ Sch Med Dept Ophthalmol Kanazawa Ku Yokohama Kanagawa 236 Japan 

出 版 物：《AMERICAN JOURNAL OF OPHTHALMOLOGY》 (美国眼科学杂志)

年 卷 期：2000年第129卷第3期

页      面：404-405页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：抗体 病毒/分析 眼房水/病毒学 巨细胞病毒/遗传学 巨细胞病毒/免疫学 巨细胞病毒/分离和提纯 DNA 病毒/分析 酶联免疫吸附测定 眼感染 病毒性/流行病学 眼感染 病毒性/病毒学 疱疹 生殖器/流行病学 疱疹 生殖器/病毒学 疱疹病毒1型 人/遗传学 疱疹病毒1型 人/免疫学 疱疹病毒1型 人/分离和提纯 疱疹病毒2型 人/遗传学 疱疹病毒2型 人/分离和提纯 疱疹病毒3型 人/遗传学 疱疹病毒3型 人/免疫学 疱疹病毒3型 人/分离和提纯 疱疹病毒4型 人/遗传学 疱疹病毒4型 人/免疫学 疱疹病毒4型 人/分离和提纯 日本/流行病学 聚合酶链反应 患病率 视网膜坏死综合征 急性/流行病学 视网膜坏死综合征 急性/病毒学 玻璃体/病毒学 青少年 成年人 老年人 女(雌)性 人类 男(雄)性 中年人 

摘      要：PURPOSE: To determine the type of herpes simplex virus in acute retinal necrosis syndrome associated with herpes simplex virus. METHODS: Herpes simplex virus type 1, herpes simplex virus type 2, varicella-zoster virus, Epstein-Barr virus, and cytomegalovirus were examined by polymerase chain reaction in intraocular specimens from 16 patients with acute retinal necrosis syndrome. Anti-herpes simplex virus type 1 and anti-herpes simplex virus type 2 type-specific antibodies in serum from the patients were detected by enzyme immunoassay. RESULTS: Of 16 patients with acute retinal necrosis syndrome, seven were polymerase chain reaction positive for herpes simplex virus type 2 and nine were positive for varicella-zoster virus, Anti-herpes simplex virus type 2 antibody was positive and antiherpes simplex virus type 1 antibody was negative in the sera of the seven patients with herpes simplex virus type 2 DNA-positive acute retinal necrosis syndrome. In contrast, anti-herpes simplex virus type 2 antibody was absent in all nine varicella-zoster virus DNA-positive acute retinal necrosis syndrome patients. CONCLUSION: Herpes simplex virus type 2 has been demonstrated to be the major causative agent in acute retinal necrosis syndrome associated with herpes simplex virus by molecular biological and serological methods. Negative preexisting anti-herpes simplex virus type 1 antibody may play an important role in acute retinal necrosis syndrome associated with herpes simplex virus type 2. (C) 2000 by Elsevier Science Inc. All rights reserved.