Antithrombin activity during the period of percutaneous coronary revascularization - Relation to heparin use, thrombotic complications and restenosis

作     者：Matthai, WH Kurnik, PB Groh, WC Untereker, WJ Siegel, JE 

作者机构：Univ Penn Sch Med Dept Med Philadelphia PA 19104 USA Univ Med & Dent New Jersey Robert Wood Johnson Med Sch Dept Med Camden NJ 08103 USA Univ Med & Dent New Jersey Robert Wood Johnson Med Sch Dept Med New Brunswick NJ 08903 USA 

出 版 物：《JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY》 (美国心脏病学会志)

年 卷 期：1999年第33卷第5期

页      面：1248-1256页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Baxter Healthcare Corporation 

主　　题：血管成形术 气囊 冠状动脉/副作用 抗凝药/治疗应用 抗凝血酶类/药物作用 抗凝血酶类/代谢 冠状血管造影术 冠心病/血液 冠心病/诊断显像 冠心病/治疗 冠状动脉血栓形成/血液 冠状动脉血栓形成/病因学 冠状动脉血栓形成/预防和控制 随访研究 肝素/治疗应用 回顾性研究 治疗结果 女(雌)性 人类 男(雄)性 

摘      要：OBJECTIVES This study evaluated changes in antithrombin (AT) activity around the time of percutaneous transluminal coronary revascularization (PTCR) with unfractionated heparin anticoagulation and the effects these changes had on major thrombotic complications of PTCR. BACKGROUND Heparin is used during PTCR to prevent thrombosis. However, heparin, a cofactor for AT, causes AT activity to fall. AT activity 20 h after heparin discontinuation. Pre-PTCR use of heparin led to lower AT activity in proportion to duration of heparin use. There was no relationship between;AT activity and restenosis. CONCLUSIONS Low AT activity may contribute to major thrombotic complications of PTCR. The way heparin is used before and after PTCR is important to development of low AT activity. (C) 1999 by the American College of Cardiology.