离子液体反胶团中青霉素酰化酶的水解反应特性

作     者：夏寒松 余江 刘会洲 XIA Hansong;YU Jiang;LIU Huizhou

作者机构：中国科学院过程工程研究所分离科学与工程实验室生化工程国家重点实验室 中国科学院研究生院北京100039 

出 版 物：《化工学报》 (CIESC Journal)

年 卷 期：2005年第56卷第10期

页      面：1932-1935页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 10[医学] 

基　　金：国家自然科学基金项目(20236050) 创新群体(20221603). 

主　　题：离子液体 反胶团 青霉素酰化酶 青霉素水解反应 6-氨基青霉烷酸 

摘      要：Penicillin hydrolysis by penicillin acylase was carried out in reversed micelle with [C14mim]Cl ionic liquids. The experi ment indicated that this catalytic reaction showed better performance in enzymat ic solubility, activity and stability than the reaction in reversed micelle with cetyl trimethyl ammonium bromide （CTAB）. For example, the maximum solubility of penicillin acylase in ionic liquids system was twice more than that in CTAB, an d the maximal enzymatic activity in ionic liquids was 1.3 times than that in CT *** outstanding properties of ionic liquids, including low charge density and irregular sharpness of head ring,might be attributable to its distinct head gro up. Ionic liquids made it possible to optimize the enzymatic catalysis in rever sed micelle through altering its interfacial structure effectively.