Barbara J. Meyer: 2018 Thomas Hunt Morgan Medal

作     者：Haloupek, Nicole 

作者机构：Genet Soc Amer Rockville MD 20852 USA 

出 版 物：《GENETICS》 (遗传学)

年 卷 期：2019年第211卷第1期

页      面：1-3页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

主　　题：Laboratories Dosage compensation Chromosomes Methylation Gene regulation Genetics Transcription Researchers Sex determination Compensation Dosage Nematodes Sexes Condensin Gene expression Careers Mitosis Medical research Meiosis Worms Structure-function relationships 

摘      要：Meyer’s work has revealed mechanisms of sex determination and dosage compensation in Caenorhabditis elegans that continue to serve as the foundation of diverse areas of study on chromosome structure and function today, nearly 40 years after she began her work on the topic. [...]Meyer did not start her academic career with plans to become a biologist. [...]the DCC shares 4 of its 10 subunits with condensin complexes involved in mitosis and meiosis (Chuang et al. 1994; Lieb et al. 1998; Mets and Meyer 2009), while other DCC subunits do double-duty with complexes involved in histone methylation (Pferdehirt et al. 2011; Brejc et al. 2017). Pferdehirt, R. R., W. S. Kruesi, and B. J. Meyer, 2011 An MLL/ COMPASS subunit functions in the C. elegans dosage compensation complex to target X chromosomes for transcriptional regulation of gene expression.