Geometric control and modeling of genome reprogramming

作     者：Caroline Uhler G V Shivashankar 

作者机构：a Department of Electrical Engineering & Computer Science and Institute for Data Systems and Society MIT Cambridge MA USA. b Mechanobiology Institute National University of Singapore Singapore. c FIRC Institute of Molecular Oncology (IFOM) Milan Italy. 

出 版 物：《Bioarchitecture》 

年 卷 期：2016年第6卷第4期

页      面：76-84页

主　　题：cell geometry chromosome organization gene expression nuclear morphology sphere packing models 

摘      要：Cell geometry is tightly coupled to gene expression patterns within the tissue microenvironment. This perspective synthesizes evidence that the 3D organization of chromosomes is a critical intermediate for geometric control of genomic programs. Using a combination of experiments and modeling we outline approaches to decipher the mechano-genomic code that governs cellular homeostasis and reprogramming.