Syntheses, characterization, DNA/HSA binding ability and antitumor activities of a family of isostructural binuclear lanthanide complexes containing hydrazine Schiff base

作     者：Song, Xue-Qing Wang, Zhi-Gang Wang, Yang Huang, Yu-Ying Sun, Yu-Xuan Ouyang, Yan Xie, Cheng-Zhi Xu, Jing-Yuan 

作者机构：Tianjin Med Univ Sch Pharm Tianjin Key Lab Technol Enabling Dev Clin Therape Tianjin Peoples R China Nankai Univ Minist Educ Key Lab Adv Energy Mat Chem Tianjin Peoples R China 

出 版 物：《JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS》 (生物分子结构与动力学杂志)

年 卷 期：2020年第38卷第3期

页      面：733-743页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 07[理学] 

基　　金：National Natural Science Foundation of China [21371135, 21401141] Tianjin Municipal Natural Science Foundation [17JCZDJC33100, 18JCYBJC91300] 

主　　题：Lanthanide-based anticancer agent hydrazine DNA interaction HSA binding A549 cell 

摘      要：Three dinuclear lanthanide complexes, [Ln(2)(L)(2)(mu(3)-OAc)(4)(H2O)(2)]center dot 2H(2)O (Ln = La (1), Eu (2) and Dy (3), HL = N -(2-hydroxybenzylidene) nicotinohydrazide), have been synthesized and characterized by IR, elemental analysis and X-ray single-crystal diffraction. Crystallographic study revealed that the representative complex 1 displays a discrete dinuclear structure with a distorted tricapped trigonal prismatic geometry around La(III) ion. The interaction of complexes 1-3 with CT-DNA was investigated by absorption spectra, fluorescence quenching and viscosity, which reveals that the complexes bind to CT-DNA with a moderate intercalative mode. The complexes exhibited obvious DNA cleavage activities in the presence of H2O2. All complexes could bind to human serum albumin (HSA) with medium affinity through static mode;thus, HSA could effectively transport complexes. Furthermore, three complexes exhibited specific cytotoxicity to A549 cancer cells in micromole magnitude than other cancer cells tested and less toxicity than cisplatin for normal human cells HUVEC, in which massive cell apoptosis was induced by complexes through producing DNA damage and suppressing DNA synthesis.