CHAOTIC DYNAMICS IN YEAST GLYCOLYSIS UNDER PERIODIC SUBSTRATE INPUT FLUX

作     者：MARKUS, M KUSCHMITZ, D HESS, B 

作者机构：Max-Planck-Institut für Ernährungsphysiologie Rheinlanddamm 201 4600 Dortmund 1 FRG 

出 版 物：《FEBS LETTERS》 (欧洲生化学会联合会快报)

年 卷 期：1984年第172卷第2期

页      面：235-238页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 07[理学] 

主　　题：Oscillation Chaos Entrainment Glycolysis Yeast PFK, phosphofructokinase(EC2.7.1.11) PK, pyruvate kinase (EC 2.7.1.40) FBP, fructose 1,6-bisphosphate F6P, fructose 6-phosphate PEP, phosphoeno/pyruvate [K tot ] and [Mg tot ], total concentrations (bound plus unbound) of potassium and magnesium F , NADH fluorescence in arbitrary units ω e , T e , frequency and period of the externally (e) applied flux ω, T , frequency and period of the system response ω 0 . T 0 , frequency and period of the system at constant input flux, i.e., without periodic excitation 

摘      要：The numerical analysis for a glycolytic model containing the enzymes phosphofructokinase and pyruvate kinase reveals different types of entrainment, as well as chaotic response under sinusoidal substrate input. Entrainment with response periods 1, 2, 3, 5 and 7-times the input flux period and aperiodic behaviour is verified by measurements of NADH fluorescence in extracts of Saccharomyces cerevisiae in the theoretically predicted range. The stroboscopic transfer function obtained from the aperiodic signal admits period 3, implying chaos according to the Li-Yorke theorem.