CARDIOVASCULAR AND ORGAN RESPONSES AND ADAPTATION RESPONSES TO HYPOGRAVITY IN AN EXPERIMENTAL ANIMAL-MODEL

作     者：BIONDI, R CAPODICASA, E TASSI, C MEZZASOMA, L BENEDETTI, C VALIANI, M MARCONI, P ROSSI, R 

作者机构：UNIV PERUGIADEPT CLIN MED PATHOL & PHARMACOLGEN PATHOL & IMMUNOL SECTI-06100 PERUGIAITALY 

出 版 物：《ACTA ASTRONAUTICA》 (宇航学报)

年 卷 期：1995年第37卷第C期

页      面：373-377页

核心收录：

学科分类：08[工学] 0825[工学-航空宇航科学与技术] 

基　　金：DRS NIH HHS [92-RS-130] Funding Source: Medline 

主　　题：乙酰氨基葡糖苷酶/代谢 乙酰氨基葡糖苷酶/尿 适应 生理学/生理学 内皮缩血管肽1/血液 内皮缩血管肽1/代谢 内皮缩血管肽2/血液 内皮缩血管肽2/代谢 头低位 后肢悬吊 大鼠 Sprague-Dawley 肾循环 腔静脉 下 腔静脉 上 失重模拟 动物 男(雄)性 大鼠 

摘      要：The head-down suspension (i.e antiorthostatic hypokinesia) rat is used to simulate weightlessness. However, little is known about cardiovascular and organ adaptation responses which, over a long time, can become pathologically significant. The purpose of this study was therefore to evaluate regional changes in the hematology parameters, Endotheline-1 (ET-I) concentration and urinary excretion of N-acetyl-beta-D-glucosaminidase (EC 3.2.1.30) (NAG) in experimental antiorthostatic rat model. The indicate significant variations in the plasma ET-I level in time, in the superior and inferior cava vessel blood of animals maintained for 10 days in hypogravity with respect to controls. These changes do not seem to be due to hemoconcentration. The increase in urinary NAG was observed during the first 24h of experiment, indicating renal stress, probably due to adverse blood flow variations within the organ. We conclude that the plasma ET-I level changes could be responsible, overall for the blood flow variations in the kidney and renal stress could be the consequence of extended antiorthostatic hypokinesia. The ET-1 behaviour and urinary NAG excretion in rats exposed to antiorthostatic hypokinetic hydynamia offer possibilities for understanding if these changes might be reversible or when they become pathological. This could give some relevant information about the effects of prolonged hypogravity during the space voyage.