Physiologic insulin delivery with insulin feedback: A control systems perspective

作     者：Palerm, Cesar C. 

作者机构：Medtron Diabet Closed Loop R&D Northridge CA 91325 USA 

出 版 物：《COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE》 (Comput. Methods Programs Biomed.)

年 卷 期：2011年第102卷第2期

页      面：130-137页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1001[医学-基础医学(可授医学、理学学位)] 0812[工学-计算机科学与技术（可授工学、理学学位）] 10[医学] 

主　　题：Biomedical control system Cascade control Medical systems Model approximation PID control Diabetes Blood glucose control 

摘      要：Individuals with type 1 diabetes mellitus must effectively manage glycemia to avoid acute and chronic complications related to aberrations of glucose levels. Because optimal diabetes management can be difficult to achieve and burdensome, research into a closed-loop insulin delivery system has been of interest for several decades. This paper provides an overview, from a control systems perspective, of the research and development effort of a particular algorithm-the external physiologic insulin delivery system. In particular the introduction of insulin feedback, based on beta-cell physiology, is covered in detail. A summary of human clinical trials is provided in the context of the evolution of this algorithm, and this paper outlines some of the research avenues that show particular promise. (C) 2010 Elsevier Ireland Ltd. All rights reserved.