Circulating exosomal miRNAs: clinical significance in human cancers

作     者：Avgeris, Margaritis Panoutsopoulou, Konstantina Papadimitriou, Maria-Alexandra Scorilas, Andreas 

作者机构：Natl & Kapodistrian Univ Athens Fac Biol Dept Biochem & Mol Biol Athens 15701 Greece 

出 版 物：《EXPERT REVIEW OF MOLECULAR DIAGNOSTICS》 (分子诊断学专家评论)

年 卷 期：2019年第19卷第11期

页      面：979-995页

核心收录：

学科分类：1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 100602[医学-中西医结合临床] 

基　　金：Stavros Niarchos Foundation, SNF National and Kapodistrian University of Athens, (GRANT ID 16785) 

主　　题：Circulating miRNA exomiR exosomes non coding RNA noninvasive biomarkers 

摘      要：Introduction: The identification of novel noninvasive biomarkers to ameliorate early-diagnosis, and disease prognosis, as well as to support personalized treatment and monitoring decisions is of first clinical priority for cancer patients? care. Exosomes are natural endosome-derived extracellular vesicles that have emerged as crucial mediators of intercellular communication and tumor progression. Considering that deregulated miRNA levels have been described in numerous human malignancies and that tumor-derived exosomes reflect miRNA expression of donor tumor cells, the evaluation of exosome-derived circulating miRNAs (exomiRs) may offer a new promising class of noninvasive molecular markers to improve patients? management and quality-of-life. Areas covered: In the current review we have summarized the existing knowledge on the clinical relevance of circulating exosomal miRNAs in improving cancer diagnosis and prognosis, and thus supporting personalized patients? management Expert commentary: Cancer research has highlighted the abundance of exomiRs in patients? plasma and serum samples, as well as their biomarker capabilities in the vast majority of human malignancies studied so far. Their analytical stability constitutes exomiRs ideal molecular markers to overcome numerous limitations of cancer clinical management, while future large-scale studies should unveil exomiRs translational utility in modern cancer molecular diagnostics.