肌成纤维细胞与血管重塑

作     者：高平进 朱鼎良 

作者机构：上海第二医科大学瑞金医院上海市高血压研究所上海200025 

出 版 物：《北京大学学报（医学版）》 (Journal of Peking University:Health Sciences)

年 卷 期：2001年第33卷第4期

页      面：313-315页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：国家重点基础研究发展规划项目基金 (973)基金 (G2 0 0 0 0 5 6 90 4)资助&& 

主　　题：成纤维细胞 肌成纤维细胞 血管重塑 血管损伤 

摘      要：Recent findings demonstrate that adventitial fibroblasts are endowed with several characteristics previously attributed to medial smooth muscle cells. Rapid activation of adventitial fibroblast, which proliferate, migrate, and undergo differentiation to myofibroblasts after balloon induced coronary injury. Myofibroblasts are involved in remodeling of adventitia and may contribute to the formation of the neointima. This review will illustrate the morphologic features, phenotypic modulation of myofibroblasts and its role in vascular remodeling, which raises the possibility of targeted therapies.