Stimulus-specificity in the responses of immune sentinel cells

作     者：Sheu, Katherine M. Luecke, Stefanie Hoffmann, Alexander 

作者机构：Institute for Quantitative and Computational Biosciences and Department for Microbiology Immunology and Molecular Genetics University of California Los Angeles 90095 CA United States 

出 版 物：《Current Opinion in Systems Biology》 (Curr. Opin. Syst.)

年 卷 期：2019年第18卷

页      面：53-61页

基　　金：NIH NIGMS NIH NIGMS T32 GM008042, (T32 GM008042) NIH R01AI127867 National Institutes of Health, NIH, (R01AI127864, R01AI127867, R01AI132835, R01GM117134) University of California, Los Angeles, UCLA 

主　　题：Combinatorial coding Dynamics Immune responses Innate immune signaling PRRs Stimulus-specificity Temporal coding Transcription factors Transcriptomics 

摘      要：Innate immune sentinel cells must initiate and orchestrate appropriate immune responses for myriad pathogens. These stimulus-specific gene expression responses are mediated by combinatorial and temporal coding within a handful of immune response signaling pathways. We outline the scope of our current understanding and indicate pressing outstanding questions. © 2019 The Authors