Model of virus therapy and chemotherapy for cancer

作     者：E Safitri T Tarmizi M Ramli S Wahyuni M Ikhwan 

作者机构：Mathematics Graduate Study Program Universitas Syiah Kuala Banda Aceh 23111 Indonesia Department of Mathematics Universitas Syiah Kuala Banda Aceh 23111 Indonesia Graduate School of Mathematics and Applied Science Universitas Syiah Kuala Banda Aceh 23111 Indonesia 

出 版 物：《IOP Conference Series: Earth and Environmental Science》 

年 卷 期：2019年第364卷第1期

摘      要：This article discusses the mathematical model of changes in the number of cancer cells as a result of the intervention. Here the effect of combination treatment, in the form of virus injection and chemotherapy on tumor cells, is presented in detail. There are two different tumor cells, uninfected tumor cells and infected tumor cells. Model simulations with different parameters were performed for 700 d. The initial values for the population of virus-infected tumor cells are divided into two categories. The number of tumor cells injected with the virus is ½ (half) and all tumor cells that are not infected. Based on the simulation results, it was concluded that the more the number of tumor cells injected with the virus, the faster the decrease in the number of tumor cell populations. It was also concluded that the reduced population of tumor cells reduces the amount of chemotherapy concentration used.