Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis

作     者：Xiaocui Xu Guoqiang Li Congru Li Jing Zhang Qiang Wang David K.Simmons Xuepeng Chen Naveen Wijesena Wei Zhu Zhanyang Wang Zhenhua Wang Bao Ju Weimin Ci Xuemei Lu Daqi Yu Qian-fei Wang Neelakanteswar Aluru Paola Oliveri Yong E.Zhang Mark Q.Martindale Jiang Liu 

作者机构：CAS Key Laboratory of Genome Sciences and InformationBeijing Institute of Genomics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute of Apiculture ResearchChinese Academy of Agriculture Sciences Whitney Laboratory for Marine Bioscience University of Florida College of Life Sciences Yantai University CAS Key Laboratory of Genomics and Precision MedicineBeijing Institute of Genomics Chinese Academy of Sciences Institute of Zoology Chinese Academy of Sciences Biology Department Woods Hole Oceanographic Institution Departments of Genetics Evolution and Environment and Cell and Developmental Biology University College London CAS Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences 

出 版 物：《National Science Review》 (国家科学评论(英文版))

年 卷 期：2019年第6卷第5期

页      面：993-1003页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：supported by the National Key Research and Development Program of China(2018YFC1003303) the Strategic Priority Research Program of the CAS(XDB13040200) the National Natural Science Foundation of China(91519306,31425015) the Youth Innovation Promotion Association of the CAS and the Key Research Program of Frontier Sciences,CAS(QYZDY-SSW-SMC016) 

主　　题：DNA methylation evolution development reprogramming 

摘      要：Major evolutionary transitions are enigmas, and the most notable enigma is between invertebrates and vertebrates, with numerous spectacular *** search for the molecular connections involved, we asked whether global epigenetic changes may offer a clue by surveying the inheritance and reprogramming of parental DNA methylation across *** focused on gametes and early embryos, where the methylomes are known to evolve divergently between fish and ***, we find that methylome reprogramming during embryogenesis occurs neither in pre-bilaterians such as cnidarians nor in protostomes such as insects, but clearly presents in deuterostomes such as echinoderms and invertebrate chordates, and then becomes more evident in *** association analysis suggests that DNA methylation reprogramming is associated with development, reproduction and adaptive immunity for vertebrates, but not for ***, the single HOX cluster of invertebrates maintains unmethylated status in all stages *** contrast, the multiple HOX clusters show dramatic dynamics of DNA methylation during vertebrate ***, the methylation dynamics of HOX clusters are associated with their spatiotemporal expression in *** study reveals that DNA methylation reprogramming has evolved dramatically during animal evolution, especially after the evolutionary transitions from invertebrates to vertebrates, and then to mammals.