Exosomes-microRNAs interacted with gastric cancer and its microenvironment: a mini literature review

作     者：Deng, Zhiyong Wu, Jianhong Xu, Song Chen, Fang Zhang, Zhiqing Jin, Anqi Wang, Jianjun 

作者机构：Jiangsu Univ Affiliated Kunshan Hosp BioBank Kunshan 215300 Jiangsu Peoples R China Jiangsu Univ Affiliated Kunshan Hosp Dept Clin Lab Kunshan 215300 Jiangsu Peoples R China Jiangsu Univ Affiliated Kunshan Hosp Dept Pathol Kunshan 215300 Jiangsu Peoples R China 

出 版 物：《BIOMARKERS IN MEDICINE》 (生物标记在医学中的应用)

年 卷 期：2020年第14卷第2期

页      面：141-150页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：Science and Technology Project of Suzhou [KJXW2018068] Science and Technology Project of Kunshan [KS1717] 

主　　题：biomarkers cancer-associated fibroblasts diagnostic strategies exosomes gastric cancer microarray analysis microenvironment miRNAs noncoding RNA therapeutic strategies tumor 

摘      要：Exosomes have appeared as fundamental vehicle-modulated crosstalk among various cells in the tumor microenvironment. The systematic understanding of exosomes in gastric cancer (GC) enhances our comprehension about the tumor growth, metastasis, chemoresistance and diagnosis of cancers. The versatile functions of exosomes provide reasonable explanations about the propensity for GC metastasis. The selectively enriched components, especially some exosomal miRNAs, are potential noninvasive biomarkers for sensitive and specific GC diagnosis. Given the characteristics of exosomes, frontier researchers are stimulated to modulate the biogenesis, concentrations or release of exosomes so as to disturb malignant signals between cells. Abnormal expression profiles of exosomal miRNAs afford potential GC therapeutic or diagnostic strategies in future.