A novel S1P1 modulator IMMH002 ameliorates psoriasis in multiple animal models

作     者：Jing Jin Nina Xue Yuan Liu Rong Fu Mingjin Wang Ming Ji Fangfang Lai Jinping Hu Xiaojian Wang Qiong Xiao Xiaoying Zhang Dali Yin Liping Bai Xiaoguang Chen Shuan Rao Jing Jin;Nina Xue;Yuan Liu;Rong Fu;Mingjin Wang;Ming Ji;Fangfang Lai;Jinping Hu;Xiaojian Wang;Qiong Xiao;Xiaoying Zhang;Dali Yin;Liping Bai;Xiaoguang Chen;Shuan Rao

作者机构：State Key Laboratory of Bioactive Substances and Functions of Natural MedicinesInstitute of Materia MedicaChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100050China Department of Thoracic SurgeryNanfang HospitalSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Quality Research in Chinese MedicineMacao Institutefor Applied Research in Medicine and HealthMacao University of Science and TechnologyTaipaMacao SAR 999078China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2020年第10卷第2期

页      面：276-288页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the CAMS Innovation Fund for Medical Sciences(2016-I2M-3-008,China) National Natural Science Foundation of China(NSFC Nos.81872923 and 81473096) Beijing Natural Science Foundation(No.7172140,China) The Drug Innovation Major Project(No.2018ZX09711001-003,China) 

主　　题：S1P1 S1P1 agonist IMMH002 Lymphocyte Psoriasis 

摘      要：Psoriasis is characterized by abnormal proliferation of keratinocytes,as well as infiltration of immune cells into the dermis and epidermis,causing itchy,scaly and erythematous plaques of *** understanding of this chronic inflammatory skin disease remains unclear and all available treatments have their limitations ***,we showed that IMMH002,a novel orally active S1 P1 modulator,desensitized peripheral pathogenic lymphocytes to egress signal from secondary lymphoid organs and *** different psoriasis animal models,we demonstrated that IMMH002 could significantly relieve skin damage as revealed by PAS I score and pathological injure ***,IMMH002 regulated CD3+T lymphocytes re-distribution by inducing lymphocytes’homing,thus decreased T lymphocytes allocation in the peripheral blood and skin but increased in the *** results suggest that the novel SIP1 agonist,IMMH002,exert extraordinary capacity to rapidly modulate T lymphocytes distribution,representing a promising drug candidate for psoriasis treatment.