Epigenetic regulation of centromere function

作     者：Wong, Charmaine Yan Yu Lee, Bernard Chi Hang Yuen, Karen Wing Yee 

作者机构：Univ Hong Kong Sch Biol Sci Kadoorie Biol Sci BldgPokfulam Rd Hong Kong Peoples R China 

出 版 物：《CELLULAR AND MOLECULAR LIFE SCIENCES》 (细胞和分子生命科学)

年 卷 期：2020年第77卷第15期

页      面：2899-2917页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：General Research Grant [17126717, 17113418] Collaborative Research Fund [C7058-18G] 

主　　题：Centromere Post-translational modifications Histone modifications Non-coding transcription Centromeric transcript Pericentric heterochromatin 

摘      要：The centromere is a specialized region on the chromosome that directs equal chromosome segregation. Centromeres are usually not defined by DNA sequences alone. How centromere formation and function are determined by epigenetics is still not fully understood. Active centromeres are often marked by the presence of centromeric-specific histone H3 variant, centromere protein A (CENP-A). How CENP-A is assembled into the centromeric chromatin during the cell cycle and propagated to the next cell cycle or the next generation to maintain the centromere function has been intensively investigated. In this review, we summarize current understanding of how post-translational modifications of CENP-A and other centromere proteins, centromeric and pericentric histone modifications, non-coding transcription and transcripts contribute to centromere function, and discuss their intricate relationships and potential feedback mechanisms.